CROSS-SECTIONAL STUDY OF ASSOCIATION BETWEEN BODY WEIGHT WITH OBESITY AND HYPERURICEMIA

Abstract

The level of uric acid level in blood is maintained by hepatic production and renal excretion. Hyperuricemia is caused by a decrease in urate excretion. Many
conditions like obesity, high cholesterol, and insulin resistance are disorders of the metabolic syndrome that are related to hyperuricemia. It occurs due to an increase in production and decrease in its excretion of urea due to renal failure which leads to further complications. The aim of study was to correlate the body weight with hyperuricemia. A cross-sectional study was conducted from September 2021 to March 2022. The total number of collected samples were 272 from patients visiting Umer Clinical Lab, Kot Adu, Pakistan and subjected for uric acid results under Microlab 300 in laboratory. Body Mass Index was calculated by measuring the weight and height. Total 272 individuals were included in this study among them, 131 (48%) were female and 141 (52%) were male. Body mass index of 272 individuals involved in this study was calculated. Out of 272 individuals, 4.04% were underweight, 32.72% were normal, 33.82% were overweight and 29.41% were obese. Serum uric acid levels were measured in 131 females and out of them 3.82% had hypouricemia, 85.50% had normal uric acid level and 10.69% had hyperuricemia. The serum uric acid levels in 141 males were measured and out of 141 males, 10.64% had hypouricemia, 82.98% had normal uric acid levels and 6.38% had hyperuricemia. Hyperuricemia in age group 41 to 60 years of both male and female were 2.84% and 6.11%, respectively. Serum uric acid levels were elevated in overweight and obese patients as compared to those who had normal weight and underweight. The majority of the participants of the study had normal weight. However, uric levels were independently associated with gender.