CANCER MECHANISM, MOLECULAR TARGETS AND CHEMOTHERAPEUTIC PHYTOCHEMICALS; A REVIEW

Abstract

The uncontrolled proliferation of cells leads to cellular accumulation, structural transformation and genetic instabilities ultimately result in the formation of malignant cells. Present day clinical manifestations for cancer management have several adverse effects including limited bioavailability, non-specificity, toxic effect on other cells or tissue.  These therapies involve chemotherapy, immunotherapy, surgery of tumours and radiotherapy and stem cell therapy. By exploring Chemotheapeutic potential of medicinal plants search for new, novel drug candidates can be explored from the thousands of year’s successful traditional medicinal system verified by the present day, advanced modern research techniques and technology. This would be beneficial for sustainable, conservable, natural resource that can  result in cost management, drug production enhancement and medicine provision or excess to the suffering population.